Abstract
Abstract Some steroids used in oral contraceptive combinations have been found to interact with cholesterol and lecithin spread as monolayers on water and to protect erythrocytes against haemolysis. No simple relation between steroid structure and these interactions was found, although in general the more water-soluble members of a group of structurally related compounds interacted to a lesser extent. No distinction could be observed in the behaviour of progestogens and oestrogens in the systems studied. It is suggested in the light of the evidence presented here and from data in the literature that these steroids may adsorb at lipid surfaces and may penetrate lipid membranes. This gives substance to the hypothesis that some steroids adsorb at platelet surfaces and alter the surface properties or the permeability of the platelet membrane sufficiently to cause increased platelet aggregation.
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