Abstract
Abstract Background: Acupuncture has been shown to regulate visceral functions. However, the specific mechanism remains unknown. Objective: This study attempted to investigate cardiac sympathetic nerve activity response to acupuncture and its activation effect on mast cells in the acupoint area. Materials and Methods: A rat model of acute myocardial ischemia (AMI) was prepared by ligating the left anterior descending artery branch. After dissecting a branch of the cardiac sympathetic nerves, the left Neiguan point (PC 6) was stimulated with acupuncture. Then, the skin tissues of acupoint area were sampled and stained with neutral red after killing the rats. Main Outcome Measures: Nerve discharges and electrocardiograph readings were recorded during acupuncture. Heart rate variability (HRV) and the power spectrum of nerve discharges were used as markers for analysis. Ratios of degranulated to total mast cells were also calculated. Results: AMI caused an increase in the ratio of low frequency/high frequency...
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