Abstract
The intestinal crypt cell assay was used to evaluate Adriamycin (ADR) and radiation injury in LAF 1 mice. The MTD (LD 01/ 60) for ADR was 8 mg/kg. Crypt cell survival was reduced to 30% of the level of survival after radiation alone when drug was given at the MTD 2 hr before or 3 hr after irradiation. Determination of crypt cell survival from −48 to +48 hr relative to 1210 rad showed little fluctuation and no evidence of a time interval yielding enhanced response. When a radiation survival curve was measured 2 hr after a dose of 8 mg/kg, it paralleled the control curve with a shift toward lower radiation doses reflecting a 70% cell kill by drug. The 3 hr split dose survival ratio of 4–6 was similar to the control values in two separate experiments. ADR appears to be toxic to intestinal crypt cells, but does not inhibit repair of radiation injury.
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