Abstract
Thirty-two human lymphoid cell lines of various origins were treated with hydrocortisone (HC) 20 μg/ml for 3 days and examined for cell viability, increase in the percentage of EBV antigen-positive cells, and interferon synthesis. Burkitt's lymphoma (BL) cell lines ( 6 9 ) under the effect of HC were characterized by a decrease in cell viability, increase in the percentage of EA antigen-positive cells, and poor interferon response in contrast to lymphoblastoid cell lines derived from the peripheral blood of normal individuals ( 0 14 ) or patients with infectious mononucleosis ( 0 4 ). The enhancement in the expression of EBV-EA as shown by the increase in the percentage of EA antigen-positive cells following HC was exclusively seen in BL cell lines ( 6 9 ). This effect could be blocked by phosphonoacetic acid (PAA). In contrast the effect on cell viability could not be inhibited by PAA but was abolished by pretreatment of the cells with interferon.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
