Abstract
ABSTRACT During incubation of minced human hyperplastic prostate tissue with [3H]5α-dihydrotestosterone (27 nm), 3H became firmly bound to macromolecules in both cytosol and nucleus. The binding to the cytosol fraction was inhibited when oestradiol-17β (0.3 μm), oestrone sulphate, ethinyl-oestradiol-17β or diethylstilboestrol (10 μm) was included in the incubation. Binding to the nuclei was inhibited by incubation with oestradiol-17β (1 μm) or cyproterone acetate (6.5 μm), a potent anti-androgen, but not by incubation with cortisol (30 μm).
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