Abstract
Solubility studies were used to determine the nature and extent of the interaction between sodium citrate and aspirin. Because of the complex nature of this system, parallel studies of the solubilizing action of sodium citrate and acetate on benzoic acid were made for purposes of comparison. The acetate-benzoic acid reaction closely followed results expected from mass law considerations over a wide concentration range. However, the weak acid-citrate interactions could be described by the mass law only at low citrate concentrations, showing wide deviations at higher concentrations. It was apparent that the deviations were a function of many variables which included changes of solubility and Ka with the nature and concentration of the solution species. The fact that the interactions could not be rationalized by these changes alone at very high citrate concentrations suggested an association or associations among the dissolved species.
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