Abstract
The effects of cholesterol upon the molecular packing of erythrocyte and myelin lipids were compared using high resolution NMR and monolayer techniques. Addition of cholesterol causes differential broadening of the lipid chain proton signal in the NMR spectra of sonicated liposomes and condenses monolayers of the sterol free lipids of the two types of membranes at the air-water interface. These effects are considered to occur due to a reduction of the configurational freedom and kinetic motions of the lipid hydrocarbon chains. Despite the differences in composition, the total lipids of both membranes give similar force-area curves indicating that the molecular packings of the isolated lipids are alike. These results are discussed with regard to the structure of erythrocyte and myelin membranes.
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