The Interaction of Chloroquine with Nucleic Acids and Nucleoproteins

Frank S Parker,J Logan Irvin

doi:10.1016/s0021-9258(18)38529-6

Abstract

The Interaction of Chloroquine with Nucleic Acids and Nucleoproteins

Highlights

AND NUCLEOPROTEINS*University, The interaction of chloroquine’ with the ribonucleic acid of yeast was reported in a preliminary paper [1]
The change in the absorption spectrum of the species +HB-B’H+ of chloroquine, which results from the binding of this species to nucleates, is dependent in part upon the molecular size of the nucleate
The absorption spectra of the species +HB-B’H+ bound to the desoxypentose nucleoprotein and to the corresponding desoxypentose nucleate are identical. In all of these cases the change in absorption spectrum involves a small shift to higher wave-lengths and a large decrease in the absorption coefficients

Summary

AND NUCLEOPROTEINS*

University, The interaction of chloroquine’ with the ribonucleic acid of yeast was reported in a preliminary paper [1]. The present paper is concerned with a study of the binding of chloroquine by the nucleoprotein and desoxypentose nucleic acid of spleen and with the presentation of additional data for the interaction of chloroquine with yeast ribonucleic acid Interactions of this type may be important in the antimalarial activity of chloroquine and in the distribution of this compound in the tissues and fluids of patients receiving this drug. The interactions with nurleate anions were studied in the range of pH 5.7 to 6.0, in which chloroquine exists solely as the species +HB-B’H+; H represents the ring nitrogen and 13’ the diethylamino nitrogen of the side chain Hereafter this species of chloroquine will be designated as the ligand and will be symbolized as L.

AND NUCLEIC

DISCUSSION

Ribonucleate Desoxypentose

SUMMARY