Abstract
Studying the effect of KCl on the Bohr effect of human hemoglobin, it appeared that at low Cl − concentration the alkaline Bohr effect is considerably smaller than it is at a Cl − ion concentration near 0.1 M. The data show that at least part of the Bohr effect, that thus far could not be attributed to a particular residue in hemoglobin, is due to interaction of hemoglobin with anions. The effect of KCl on the Bohr effect shows a striking similarity with the effect of 2,3-diphosphoglycerate (DPG) on the Bohr effect. Based on this a mechanism is proposed which satisfactorily explains the observed salt effect.
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