Abstract
Posttraumatic stress disorder (PTSD) results from direct or indirect exposure to trauma or highly stressful circumstances. The situations that precipitate PTSD can vary in frequency, extent, intensity, and amount of exposure. The twin study by Vaccarino et al. (1) in the current issue of Biological Psychiatry is an important and appropriately designed longitudinal study of PTSD and ischemic myocardial blood flow in 283 adult male twins from the Vietnam Era Twin Registry. The cardiovascular disease phenotype of ischemia resulting from impaired microvascular function was assessed using positron emission tomography myocardial blood flow (MBF) responses to adenosine stress.
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