Abstract
Abstract Angiotensin II infusion into normal human subjects increases the plasma concentration of aldosterone and 18-hydroxycorticosterone but leaves those of other corticosteroids unaffected. This contrasts with the response of adrenocortical cells in vitro . However, if a low, constant rate infusion of ACTH is maintained throughout increasing rates of angiotensin II infusion, the concentrations of cortisol, corticosterone and 18-hydroxy-11-deoxycorticosterone also correlate positively and significantly with the prevailing angiotensin II concentration. Plasma 11-deoxycorticosterone levels also rise. A possible explanation of this finding is that the presence of ACTH is necessary for a full corticosteroid response to angiotensin II and that infused angiotensin II inhibits ACTH secretion.
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