Abstract
The interaction between copper–zinc superoxide dismutase (Cu–Zn SOD) and anthracycline antitumour drugs (doxorubicin and 4′-epidoxorubicin) has been investigated by e.s.r. spectroscopy. The Cu2+ centres within the enzyme structure are available for anthracycline coordination in a way similar to that observed for copper-anthracycline derivatives when CuCl2 was used and at high r values (where r is the anthracycline/Cu2+ molar ratio). The amount of copper extracted by the drug increases as the protein concentration decreases, and several stacked anthracycline units are found to bind to one Cu2+ centre.
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Schedule a callMore From: Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases
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