Abstract
The circular dichroism (CD) spectra of complexes between aromatic hydrocarbons and quinolines with DNA and complexes between proflavine and nucleic acids have been measured. The CD spectra of aromatic hydrocarbons and quinolines bound to DNA show a positive or a negative band in the region of the absorption spectra of these small molecules bound to DNA. This was the general pattern of CD spectra by the monomeric small molecules bound to DNA. In the denatured DNA-proflavine or RNA-proflavine complex, a new type of CD spectrum is observed which is considered to be due to the stacking dye-dye interaction. Induced Cotton effects were observed also for the complexes with a single-stranded DNA obtained by dilution denaturation at neutral pH. This indicates that even the single-stranded DNA retains some rigidity in which helical structure is maintained by interbase stacking.
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