The interaction between self-care behavior and disease knowledge on the decline in renal function in chronic kidney disease

Yi-Chun Tsai,Pei-Ni Hsiao,Hung-Chun Chen,Shu-Li Wang,Shang-Jyh Hwang,Hui-Ju Tsai,Shih-Ming Hsiao,Yi-Wen Chiu,Tzu-Hui Chen,Lan-Fang Kung

doi:10.1038/s41598-020-79873-z

Abstract

Multidisciplinary care can improve the outcomes of chronic kidney disease (CKD), however the contribution of self-care behavior and knowledge about CKD is unclear. This study enrolled 454 participants with CKD stages 1–5 not on dialysis. Structured questionnaires were used to evaluate self-care behavior and kidney disease knowledge. Rapid decline in renal function was defined as the decline in estimated filtration rate > 3 ml/min per 1.73 m2/year within 1-year prior to enrollment. The mean age of all study participants was 65.8 ± 12.1 years and 55.9% were male. The elderly had better self-care behavior while younger participants had better disease knowledge. Both high self-care and high disease knowledge scores were significantly associated with and had a synergistic effect on decreasing the risk of rapid decline in renal function. CKD patients with better self-care behavior and better kidney disease knowledge had lower risk of rapid decline in renal function.

Highlights

Multidisciplinary care can improve the outcomes of chronic kidney disease (CKD), the contribution of self-care behavior and knowledge about CKD is unclear
High self-care behavior and high disease knowledge were defined as scores ≥ 67 and 22 respectively, while low self-care behavior and low disease knowledge were defined as scores < 67 and 22 respectively
To the best of our knowledge, this is the first study to evaluate the association of self-care behavior, disease knowledge and their interaction with the decline in renal function in patients with CKD enrolled in a multidisciplinary care program

Summary

Introduction

Multidisciplinary care can improve the outcomes of chronic kidney disease (CKD), the contribution of self-care behavior and knowledge about CKD is unclear. The elderly had better self-care behavior while younger participants had better disease knowledge Both high self-care and high disease knowledge scores were significantly associated with and had a synergistic effect on decreasing the risk of rapid decline in renal function. CKD patients with better self-care behavior and better kidney disease knowledge had lower risk of rapid decline in renal function. The aims of this study were to analyze the factors related to self-care behavior and disease knowledge and retrospectively to examine the association of the interaction between these two components with decline in renal function (estimated glomerular infiltration rate (eGFR) slope) in patients with CKD

Objectives

Methods

Results

Conclusion