Abstract
The interaction between cholinergic and β-adrenergic systems on radial arm maze performance was investigated. Scopolamine significantly disrupted radial maze performance. Although neither propranolol (a centrally and peripherally acting β-antagonist), nor atenolol (a peripherally acting β1-antagonist) affected the maze performance, both antagonists significantly augmented the scopolamine disruption. These results suggest the importance of the interaction between central cholinergic and peripheral β-adrenergic systems on radial maze performance.
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