Abstract
Summary. We analyzed plasma level of an inflammatory mediator lipoxin A4 in patients with chronic obstructive pulmonary disease (COPD) which could be used as a marker of systemic inflammation in COPD patients. Relationships between the lipoxin A4 level and cellular markers of inflammation, persistent lipid peroxidation and reduced exercise tolerance have been found. Improvement in lipoxin A4 level could be an attractive contribution to rehabilitation of COPD patients and should be considered in predictive multivariable models of clinical course and in therapeutic algorithms.
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