Abstract

In the development of filtered radon implants, a great deal of work was necessary before they were used clinically. Much of this has already been reported (1), (2). Since these papers were written, additional data have been accumulated. It is the purpose of this paper to correlate the available information, and to show that it may be represented by a single curve, which is directly applicable to dosage problems. Three distinctly different reactions have been used in obtaining these data: (a) tissue necrosis; (b) butter decoloration; (c) skin erythema. The first two are used in the papers referred to above, and are fully discussed there. The work will be summarized briefly here, and the experimental data taken directly from those papers. (a).-Tissue Necrosis. From the clinical aspect, one of the most important considerations in the use of buried radon is the relation between the strength of the tube and the volume of necrosis produced. This was investigated experimentally by burying tubes of varying radon ...

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