The Intensity of Degradation and Synthesis of Derma Intercellular Matrix in Rats after Local Cold Injury in the Presence of Metabolic Syndrome

Abstract

Studies of tissue regeneration processes in the post-cold period are currently in demand in connection with the development of the Arctic, which is characterized by extremely low temperatures. Metabolic or hormonal abnormalities based on insulin resistance and compensatory hyperinsulinemia, which can lead to the development of cardiovascular diseases, and, consequently, to microcirculation disorders, are aggravating factors that increase the consequences of cold injuries. In this work, we studied the processes of degradation and synthesis of the intercellular matrix of the dermis, as well as the concentration of sialic acids in the blood serum after a local cold injury of the third degree. It was revealed that the regenerative process after local cold damage began on day 3 and was characterized by an increase in the collagen content of the dermis and the thickness of collagen fibers. Regeneration in the case of metabolic syndrome was accompanied by a slowdown in tissue repair processes. The course of the recovery process was associated with a change in the content of sialic acids in the blood serum, while a distinctive feature of the dynamics of this indicator was an increase in the concentration of sialic acids in metabolic disorders on day 7 and a slow slight decrease throughout the experiment, reaching the control values by day 21.