Abstract
Herein we present major updates to the National NeuroAIDS Tissue Consortium (NNTC) database. The NNTC's ongoing multisite clinical research study was established to facilitate access to ante-mortem and post-mortem data, tissues and biofluids for the neurohuman immunodeficiency virus (HIV) research community. Recently, the NNTC has expanded to include data from the central nervous system HIV Antiretroviral Therapy Effects Research (CHARTER) study. The data and biospecimens from CHARTER and NNTC cohorts are available to qualified researchers upon request. Data generated by requestors using NNTC biospecimens and tissues are returned to the NNTC upon the conclusion of requestors' work, and this external, experimental data are annotated and curated in the publically accessible NNTC database, thereby extending the utility of each case. A flexible and extensible database ontology allows the integration of disparate data sets, including external experimental data, clinical neuropsychological and neuromedical testing data, tissue pathology and neuroimaging data.
Highlights
Advances in treatment and the development of combination antiretroviral therapy have reshaped the long-term outlook for individuals living with human immunodeficiency virus (HIV)
These disorders include mild to moderate findings of neurocognitive disorders, HIV-associated dementia and peripheral neuropathy associated with HIV infection and neurotoxic antiretroviral treatment (ART) use [3, 4]
This paper describes the approach taken by the National NeuroAIDS Tissue Consortium (NNTC)–data coordination center (DCC) for the creation of an integrated neuroHIV research database
Summary
Advances in treatment and the development of combination antiretroviral therapy have reshaped the long-term outlook for individuals living with human immunodeficiency virus (HIV). The National NeuroAIDS Tissue Consortium (NNTC) is composed of four national clinical sites and a data coordination center (DCC) that work cooperatively as a resource for the neuroHIV research community. The DCC became responsible for housing the clinical research data from an additional study of HIV and the nervous system, the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) study (comprised of six national clinical sites, three of which are NNTC sites) [7] and external experimental data from CHARTER biospecimen requestors.
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