Abstract
Summary Gymnema sylvestre, R.Br. a woody climber, growing in unkempt tropical forests of Southern India belonging to the family of Asclepiadaceae has been in use in the treatment of diabetes mellitus in India for over 2000 years. Scientific investigation of the biological effect of oral administration of the leaves revealed that it is able to increase the circulating insulin levels in alloxan diabetic rabbits and in a single maturity-onset diabetic patient. The hypoglycemic action of the leaf powder is not abrupt and severe, but slow. Blood glucose homeostasis during G. sylvestre therapy is associated with lowering of the serum lipid levels.
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