Abstract
The resting membrane potential, E m , and the cell input resistance, R i n p , of cultured human Chang liver cells were measured using the single electrode ‘double-pulse’ current clamp technique, following exposure of the cells to the insecticide DDT (20 μM). In control (unexposed) cells, the mean E m was −24 mV, and the mean R inp was 30 MΩ. Neither parameter was significantly impaired after 1 h of cell exposure to DDT. But after 7 and 48 h, the E m was depolarized by 15 and 25 mV, respectively, in parallel with a decrease of the cell input resistance. The strongly time-delayed effect of DDT on Chang liver cell membranes may indicate a mode of interaction different from excitable membranes.
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