Abstract
Combined scanning (SEM) and transmission (TEM) electron microscopy was done on external features of human intracranial arteries, including large vessels at the base of the brain and secondary and tertiary branches of the middle and posterior cerebral arteries. Linear structures lying on the external surface of these arteries could be easily identified and followed for distances of several millimeters. These were well-circumscribed and often branched before disappearing into the depths of the adventitia. With TEM the linear structures observed with SEM could be identified as bundles of myelinated and unmyelinated axons embedded in collagenous fibrils, with surrounding perineurial sheaths composed of overlapping fibrocyte processes. The scanning electron microscope provides a striking and relatively simple method for studying the extent and distribution of vascular innervation.
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