Abstract
The incidence of lymphomata in CBA mice is low and furthermore is unaltered by transplantation at the early blastocyst stage and being born from the lymphoma-prone AKR. The number of C-type murine leukaemia virus particles in CBA derived in this manner and milk-fostered by AKR mice in no way differs from normal CBA. The results suggest that the oncogenic Gross virus does not pass through either the transplacental or transmammary routes, or alternatively that viral replication in the CBA was in some way inhibited. Both possibilities have still to be distinguished.
Highlights
Summary.-The incidence of lymphomata in CBA mice is low and is unaltered by transplantation at the early blastocyst stage and being born from the lymphoma-prone AKR
Absence of tumours in this situation could have been due either to the failure of oncogenic virus transmission to the transplanted CBA embryo, or to suppression of the oncogenic activity of the virus. We have investigated another group of CBA mice derived by embryo transfer, born and milk-fostered by AKR, for the presence of C-type murine leukaemia virus particles
As in normal CBA (Fig. 1), and in marked contrast to the AKR controls (Fig. 2), very few C-type virus particles were seen in the tissues of any of the embryo transfer-derived CBA
Summary
Summary.-The incidence of lymphomata in CBA mice is low and is unaltered by transplantation at the early blastocyst stage and being born from the lymphoma-prone AKR. The results suggest that the oncogenic Gross virus does not pass through either the transplacental or transmammary routes, or alternatively that viral replication in the CBA was in some way inhibited. Both possibilities have still to be distinguished. We have investigated another group of CBA mice derived by embryo transfer, born and milk-fostered by AKR, for the presence of C-type murine leukaemia virus particles
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