The innate immune pattern-recognition receptor CD14 influences osteoclastogenesis and the persistence of synovial leukocyte infiltration after joint injury in mice

Abstract

Purpose: CD14 is a macrophage co-receptor that facilitates Toll-like receptor signaling. Deficiency of CD14 protects mice from subchondral bone pathology and progression of cartilage degeneration in a murine model of post-traumatic OA. CD14 is highly expressed by myeloid cells including monocytes, macrophages, and osteoclast precursors and can influence activity of these cell types. Binding of TLR ligands to the CD14/TLR complex activates inflammatory signaling cascades and promotes chronic inflammation, and many TLR ligands have been implicated in OA pathogenesis.