Abstract

背景与目的肺段切除较肺叶切除能够更多地保留健康肺组织,但其在早期肺癌根治性方面仍存在争议。本研究分析35例完全胸腔镜下解剖性肺段切除术临床病理资料并复习文献,探讨胸腔镜下肺段切除术在早期肺癌治疗中面临的问题。方法回顾北京大学第三医院2013年5月-2017年7月单一手术组35例完全胸腔镜下肺段切除术患者的临床病理资料,观察术中及术后并发症等安全性指标及淋巴结清扫数目、转移情况,并将术后病理类型与术前影像类型比对分析。35例肺段切除术中男性11例,女性24例,平均年龄57.7岁。病灶位于右肺上叶者8例,右肺下叶者8例,左肺上叶者13例,左肺下叶者6例。计算机断层扫描(computed tomography, CT)影像学肿瘤最大径平均12.7 mm,肺门及纵隔淋巴结最大直径均小于10 mm,以磨玻璃成为主者23例,以实性成分为主者12例。结果35例均顺利完成电视辅助胸腔镜手术(video-assisted thoracic surgery, VATS)解剖性肺段切除术,平均手术时间为153 min,出血量为51 mL。术后漏气10例,均未超过3天。健侧肺不张1例,乳糜胸1例。平均住院时间为6.1天。出院后30天内门诊复查未发生其他院外手术相关并发症。病理为转移瘤者2例,良性肺病8例,原发肺癌25例。25例原发肺癌中浸润性肺腺癌14例[CT以肺磨玻璃影(ground-glass opacity, GGO)为主者7例],微小浸润腺癌4例(GGO为主者3例),原位腺癌6例(CT均为纯GGO),肺鳞癌1例(CT以实性成分为主)。25例肺癌平均切除淋巴结7.2枚,所有淋巴结无癌转移。结论VATS解剖性肺段切除术技术上安全可靠,其在肺癌治疗中适应症需严格掌握,其优势仍需前瞻性随机对照实验来证实。

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