Abstract
A simple metal—plastic implant was found to inhibit the growth of Walker 256 carcinoma in 200 out of 230 animals. In 126 animals no macroscopically identifiable tumour mass was evident and in 74 animals a very inhibited tumour nodule was found. In the remaining 30 animals tumour growth was observed around the implant. Detailed histological studies revealed that the implant had a profound inhibitory influence on the proliferative behaviour of the tumour. Where only partial inhibition of tumour growth occurred, distinctive patterns of tumour cell distribution and cellular proliferation were observed suggesting that the implants established a field effect in the tumour tissue.
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