Abstract
Ethoxyquin (EQ), a widely used antioxidant, inhibits the carcinogenic effects of polycyclic aromatic hydrocarbons. The aim of the present study was to determine whether EQ modifies the hepatocarcinogenic effects of aflatoxin B 1 (AFB 1) in rats. Both compounds were administered in the diet. Rats were fed either EQ for 2 weeks and then AFB 1 for 6 weeks, EQ and AFB 1 simultaneously or EQ following the cessation of AFB 1 treatment. The results indicate that EQ can inhibit the hepatocarcinogenic effects of AFB 1 and that the most effective inhibition is obtained when EQ and AFB 1 are given simultaneously.
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