Abstract
Rats fed a diet containing 0.25% acetylsalicylic acid for a period of 5 weeks grew normally and did not exhibit symptoms characteristic of toxicity. Acetylsalicylic acid feeding decreased the concentration of glycogen in liver, the activities of pyruvate carboxylase and phosphoenolpyruvate carboxykinase in liver, and the activity of phosphoenolpyruvate carboxykinase in kidney. The activities of glucose-6-phosphatase and fructose-1,6-diphosphatase in liver and pyruvate carboxylase in kidney were not affected. Intraperitoneal injection of acetylsalicylate (5 mg/100 g body wt.) to control rats and in vitro addition of acetylsalicylate (5mM) to the enzyme assays did not inhibit any of the tested enzymes. The findings suggest that chronic acetylsalicylic acid ingestion may inhibit gluconeogenesis by decreasing the activities of the regulatory enzymes.
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