Abstract
β-Momorcharin purified from the seeds of Momordica ucharantia L. suppressed the decidual response of pseudopregnant mouse uterus to mechanical stimulus. In the β-momorcharin-treated uterus, stromal cells failed to decidualise, uterine glands distended, and a diminished cell proliferation was found in the endometrium and myometrium. β-Momorcharin also inhibited the biosynthetic activity of the cultured endometrial cells. The rate of incorporation of 3H-thymidine, 3H-uridine and 3H-leucine was all depressed by β-momorcharin. The termination of the early pregnancy in the mouse may have resulted from an inhibitory effect of the abortifacient protein on the differentiating endometrium.
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