Abstract
The inhibitory effect of 7-ketocholesterol on the cholesterol uptake by arteries has been examined. Solubilized 7-ketocholesterol injected into hepatectomized rabbits failed to inhibit cholesterol uptake by their aortas in vivo. There was also no inhibition of cholesterol uptake when rabbit carotid artieries were perfused in vitro with plasma pooled from hepatectomized animals injected with solubilized 7-ketocholesterol. However, significant inhibition of cholesterol uptake by pig coronary arteries was demonstrated when these vessels were perfused with isologous plasma containing particulate 7-ketocholesterol. It was concluded that only particulate but not solubilized 7-ketocholesterol is responsible for the inhibition of cholesterol uptake by arteries. The results presented here are supported by the previous findings in the literature that suspended 7-ketocholesterol inhibits cholesterol uptake by cultured human fibroblasts.
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