Abstract
Red cell membrane and brain tissue ATPase were inhibited by δ-aminolaevulinic acid. The effect was on the (Na + + K +)-dependent fraction of ATPase, and δ-aminolaevulinic acid had no effect on the magnesium-dependent fraction of ATPase. The effect of δ-aminolaevulinic acid was reversible. δ-Aminolaevulinic acid had no effect on ATPase enzyme activity on red cell ghost membranes. The difference between red cell membrane and brain tissue ATPase, on the one hand, and red cell ghost membrane ATPase on the other hand may be due to the solubility of the ATPase enzyme in the different experiments. Glycine, cysteine hydrochloride and sodium phenobarbitone had no effect on red cell membrane and brain tissue ATPase enzyme. The findings suggest a possible explanation for the neurological manifestation of acute intermittent porphyria and porphyria variegata, since the inhibition of (Na + + K +)-dependent nerve ATPase by δ-aminolaevulinic acid could block nerve conduction and cause paralysis.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Biomembranes
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