Abstract
Abstract 2-Deoxy- D -glucose causes and inhibition of the oxidation of palmitate C- I to CO 2 , but not of acetate C- I to CO 2 in ascites tumor cells. While inhibiting the oxidation of exogenous palmitate, addition of deoxyglucose does not impair the oxidation of palmitate incorporated into the cellular lipids or of palmitate taken up by cells during a short period of preincubation. The oxidation of exogenous palmitate is only slightly decreased in cells previously incubated with deoxyglucose and containing a low level of ATP and a high level of deoxyglucose 6-phosphate. The results suggest that deoxyglucose affects the uptake or the activation, but not the oxidative degradation of the fatty acid. The preferential utilization of newly formed ATP for deoxyglucose phosphorylation, rather than the induced low intracellular ATP level or the presence of the deoxyglucose 6-phosphate, appears to be inhibitory to exogenous palmitate utilization.
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