Abstract
Abstract The succinoxidase and pyruvic-oxidase activities as well as the accompanying phosphorylation were shown to be inhibitied by 2,3-dimethoxy-5-methyl-6-bromo- p -benzoquinone and 2,3-dimethoxy-5-methyl-6-bromo- p -benzoquinone in beef-heart mitochondria. The inhibitory effects of these quinones were reversed by addition of cysteine or glutathione. The protective action of these sulfhydryl compounds could be explained in terms of an SH-addition reaction with the 2,3-dimethoxy-5-methyl-6-bromo- p -benzoquinone and 2,3-dimethoxy-5-methyl-6-bromo- p -benzoquinone can serve as electron carriers and thus bypass certain endogenous carriers of the elelctron-transport chain. These benzoquinones inhibit oxidative phosphorylation by at least two mechanisms: (a) reacting with vital sulfhydryl groupings in the electron transport and phosphorylation system and (b) acting as agents which can shunt elections through a non-phosphorylating pathway.
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