Abstract
Summary Crotalase is rapidly inhibited by the specific plasma kallikrein inhibitor prolylphenylalanyl-arginine chloromethyl ketone. The peptide chloromethyl ketones representing the sequences cleaved by thrombin in coagulation factor XIII (valyl-prolylarginine chloromethyl ketone), in prothrombin (isoleuyl-prolyl-arginine chloromethyl ketone) and in the A(α) chain of fibrinogen (glycyl-valyl-arginine chloromethyl ketone), are much less effective inhibitors of crotalase than is prolyl-phenylalanyl-arginine chloromethyl ketone.
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Schedule a callMore From: Biochemical and biophysical research communications
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