Abstract
The cow-liver, catalase was inhibited by 3-nitropropionate (3-NPA) at every pH tested. The 50% inhibition degree, ϕ, of 3-NPA under experimental condition was 8.7 × 10‒4 M, which was almost that of phenol (1.0 × 10‒3 M). Among 3-NPA, 1-nitropropane, and propionate, 3-NPA had the most effective inhibitory effect. The maximum absorption spectrum of free catalase in the Soret region was not shifted clearly by an addition of 3-NPA, but the intensity of it was decreased. The inhibition type of 3-NPA was riot definitely classified as the cyanide type. Results indicate that this inhibition essentially be due to reaction between the prosthetic group and anion form of nitro group in 3-NPA, and that the inhibitory action of nitro group may be stimulated by carboxylic group. Finally, this inhibition could be thought as a partial toxic cause in vivo.
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