Abstract
A large number of the urinary constituents have been reported to inhibit calcium oxalate crystal growth and aggregation. Pyrophosphate, for example, is a potent inhibitor of crystal growth1 and glycosaminoglycans potent inhibitors of crystal aggregation2. Regarding urinary macromolecular inhibitors of calcium oxalate crystallization, a number of substances such as glycosaminoglycans2, polypeptides3, polyribonucleotides4 and glycoproteins5 have been claimed to be of importance. There has also been a debate as to whether uromucoid or Tamm-Horsfall glycoprotein is a promoter or an inhibitor of the crystallization process6. The purpose of the present study is to compare the inhibition of calcium oxalate crystal growth by pyrophosphate, polyanionic glycosaminoglycans and Tamm-Horsfall glycoprotein. This comparison has also been extended to include two drugs with a structure similar to pyrophosphate and heparin respectively.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
