Abstract
Objective To observe the effects of As 2 O 3 on malignant\|ascites of nude mice and probe into its mechanism of action.Methods BALB/c\|nu/nu nude mice were injected with MKN\|45 gastric cancer cell line and were divided into 5 groups at random : normal saline , Epirubicin and various concentration groups of As 2 O 3 . The rate of tumor formation, production of ascites and survival period were evaluated. Morphorlogical changes of tumor cell were studied by electromicroscope.Results Epirubicin and low dose of As 2 O 3 can obviously inhibit the production of ascites and prolongs the survival period of tumor\|loading nude mice ( P 0.01). Mid to high doses of As 2 O 3 can erate cancer cells through the way of apoptosis.Conclusion As 2 O 3 can induce gastric cancer cell apoptosis, inhibit or erate production of ascites and prolong the survival period of nude mice that suffered from malignant ascites from metasasis.
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