Abstract
An egg production strain of New Hampshire chickens was investigated to determine the mode of inheritance of resistance to subgroup C Rous sarcoma virus (R.S.V.). Assays were performed on the chorioallantoic membrane (CAM) and on chick embryo fibroblasts (C.E.F.). Segregation ratios for resistance to subgroup C R.S.V. agreed with the hypothesis of a single autosomal recessive gene controlling resistance to this subgroup. The allele for susceptibility was found to be completely dominant to the allele for resistance. The mechanism of resistance for the subgroup C viruses appears to be the same as that found for the A and B subgroups; that is, the cells are not only resistant to transformation, but also to viral infection.
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