Abstract
F1 hybrid mice from crosses between the lipopolysaccharide (LPS) nonresponder strain C3H/HeJ and a variety of LPS responder strains show quantitative or codominant inheritance of mitogenic responsiveness to LPS. Backcross segregation ratios indicate that a defect at a single locus is responsible for the lack of responsiveness in C3H/HeJ mice. Autoradiographic studies show that the number of LPS-responsive cells in F1 cultures is approximately half the number of responsive cells in parent cultures. Kinetic patterns of mitogenic responsiveness to LPS differ in F1 hybrid and parent cultures. The kinetic patterns of responsiveness vary with the cell concentrations of the culture and appear to correlate with the number of LPS-responsive cells in F1 and parent cultures.
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