Abstract
Objective To explore the cerebrovascular reserve in the type 2 diabetel mellitus (T2DM) by transcranial doppler sonography (TCD) combined with breathholding test(BHT) and to explore the changes of the cerebrovascular reserve after the patients received the different interventions. Methods Sixty elderly T2DM and 60 health controls were selected. The clinical data about the breath-holding index were collected. The diabetics were randomly divided into three groups: the rehabilitation exercise group (n=20), the NBP group (n=20) and the Flunarizine hydrochloride group (n=20). Each group has received the corresponding treatment for six months.All patients were valued by TCD combined with BHT to evaluate intracranial vascular reaction and then the breath-holding index (BHI) were calculated. Results Before the treatment, there was a statistically significant difference between thediabetic group (BHI 0.49±0.08) and the control group (BHI 0.55±0.05) (t=-5.59, P 0.05), while the NBP group had an significant increasing trend (0.54±0.07, 0.50±0.08, t=1.72, P=0.01). Conclusion The cerebrovascular reserve in the aged diabetics are declined. The NBP may improve the cerebrovascular reserve of diabetics. Key words: Ultransonography, doppler, transcranial; Cerebrovascular circulation; Diabetes mellitus, Type 2
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