The influences of cardiac mechano-electrical feedback on action potential duration

J.-C Hsieh,Shih-Ann Chen Shih-Ann Chen,J.K.-J Li,Cheng-Jeng Tai Cheng-Jeng Tai

doi:10.1109/iembs.1999.802184

The influences of cardiac mechano-electrical feedback on action potential duration

J.-C Hsieh, Shih-Ann Chen Shih-Ann Chen + Show 2 more

https://doi.org/10.1109/iembs.1999.802184

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Publication Date: Oct 13, 1999

Citations: 3

Affiliation: National Yang Ming Chiao Tung University, Taipei Veterans General Hospital, Rutgers, The State University of New Jersey, Xi'an Peihua University

#Action Potential Duration #Shortening Of Action Potential Duration + Show 8 more

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Abstract

A mathematical model of ventricular tissue, incorporated into stretch-activated channels (SACs) and volume-activated chloride currents (I/sub cl,swell/), was developed to investigate the interactions between cellular geometry and gap junctions in modulating action potential duration (APD). Results showed that shortening of APD was observed by activation of SACs using sustained axis-stretch in cellular uncoupling; however, lengthening of APD was observed in cellular coupling. Shortening of APD was observed by activation of I/sub cl,swell/ using radial swelling in both coupling and uncoupling. Thus, the alteration of APD by mechano-electrical feedback (MEF) in various gap junctions can be arrhythmogenic.

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