Abstract
The influence ofin vivo tributyltin (TBT) exposure on macrophage activation was compared to previously reported responses resulting fromin vitro exposure. Oyster toadfish (Opsanus tau) were treated weekly for six weeks with either sham, vehicle, 0.250, 0.750, or 2.5 mg/kg TBT. Resident peritoneal macrophages were isolated and chemiluminescence (CL) stimulated by TBT (50 μg/L) and synergistic combinations of the tumor promoter myristate acetate (PMA) and calcium ionophore (A23187) was compared between treatment groups. Chemiluminescence was reduced in a dose-dependent manner in response to both PMA + A23187- and TBT (50 μg/L)-stimulation.
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