Abstract
PENTO, J. T., AND KENNY, A. D. The Influence of Whole-Body Irradiation on Calcium and Phosphate Homeostasis in the Rat. Radiat. Res. 63, 468-473 1975. Previous irradiation studies have revealed marked alterations in calcium metabolism. Moreover, the maintenance of calcium homeostasis with parathyroid hormone or calcium salts has been reported to reduce radiation lethality. Therefore, the present study was designed to evaluate the influence of irradiation on calcium homeostasis in the rat. Nine hundred rad of whole-body irradiation produced a significant depression of both plasma calcium and phosphate at 4 days postirradiation. This effect of irradiation was observed to be dose-dependent over a range of 600-1200 rad, and possibly related to irradiation-induced anorexia. The physiological significance of these observations is discussed.
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