THE INFLUENCE OF VITAMIN D RECEPTOR GEN 283 A>G (BSMI) POLYMORPHISM ON OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN

Abstract

Objective: to study associations between VDR gene 283 A>G (BsmI) polymorphism and osteoporotic changes in various sites of skeleton in postmenopausal women. Materials and methods: 525 postmenopausal women were examined. The densitometry was carried out by dual energy X-ray absorptiometry. VDR gene 283 A>G (BsmI) polymorphism was investigated by the realtime PCR method. Results: this investigation determined correlation (P<0,05) between mineral density of lumbar vertebrae L1-L4, left and right proximal femoral neck and total hip, distal forearm of not dominant arm and women body weight (rs from 0,36 to 0,54), body mass index (rs from 0,28 to 0,42), postmenopausal period duration (rs from -0,13 to -0,51). The osteoporosis at L1-L4 lumbar vertebrae had associations with GG genotype (Р=0,009) and G allele (Р=0,016) of VDR gene 283 A>G (BsmI) polymorphism. Correlation between 283 A>G (BsmI) polymorphism and osteoporotic changes in proximal femoral neck and total hip, distal forearm was not established (P>0,05). Conclusions: the obtained data can be used for detection of predisposition to osteoporosis development in postmenopausal women and treatment-and-prophylactic actions efficiency risings.