The Influence of Viscosity and Non-freezing Water Contents Bounded to Different Hydroxypropyl Celluloses (HPC) and Hydroxypropyl Methylcelluloses (HPMC) on Stability of Acetylsalicylic Acid

Abstract

The aim of the study was to examine the influence of non-freezing water (NFW) contents bound to hydroxypropyl methylcellulose (HPMC) or hydroxypropyl cellulose (HPC) binary mixtures using acetylsalicylic acid (ASA) as a model moisture-sensitive ingredient. Polysaccharides with significantly different physicochemical properties were mixed with acetylsalicylic acid at a ratio 1:1 (w/w). The measurements of NFW contents of hydrated samples were carried out using differential scanning calorimetry (DSC). In the method used, the dry mass normalized dependency of melting enthalpy (ΔH) and respective contents of water was found to be linear. NFW values were calculated after extrapolation ΔH to 0. For stability studies, HPC/ASA and HPMC/ASA mixtures were stored at 40°C and 75% RH for 5 weeks in the climatic chamber. The ASA hydrolysis was investigated using UV-Vis spectrophotometry. The amounts of NFW calculated for raw HPMC 3 cP and 100,000 cP were 0.49 and 0.42 g g−1, while for polymer and ASA mixtures, prepared from HPC type LF (126 cP) and MF (6300 cP) as well as from HPMC 3 cP and 100,000 cP were 0.23, 0.28 g g−1, 0.21 g g−1, and 0.33 g g−1 respectively. The measured NFW values were connected with appropriate concentrations of unhydrolyzed ASA.