Abstract
The Influence of Various Drags on Mortality of Mice and the Concentration of Proinflammatory Cytokines in Blood at Sepsis Caused by E. Coli
Highlights
From all the lethal outcomes associated with diseases and their complications, mortality from sepsis, including that caused by opportunistic Gram-negative microorganisms (E .coli, etc.) varies from 12 to 60% depending on various factors [1], and the frequency of lethality from it increases [2,3]
The results indicate that the applied drags, both cholinomimetics, and agonists reduced the mortality of mice from sepsis approximately the maximum effect was observed when applying α7nAChRs agonist (GTS-21), minimal effect - when using m-cholinomimetic aceclydine
Theuseofm-holinomimetic(aceclydine),n-cholinomimetic, reversible inhibitor of acetylcholinesterase, n-cholinomimetic α7nAChRs agonist (GTS-21), epinephrine hydrochloride, adenomimetic β2ARs agonist causes a decrease in mice mortality in sepsis caused by the administration i.p. of E. coli O157:H7
Summary
From all the lethal outcomes associated with diseases and their complications, mortality from sepsis, including that caused by opportunistic Gram-negative microorganisms (E .coli, etc.) varies from 12 to 60% depending on various factors [1], and the frequency of lethality from it increases [2,3]. Further study of the cholinergic anti-inflammatory pathway caused by the action of acetylcholine on α7n-acetylcholinoreceptors (α7nAChRs) of cells of the monocyte-macrophage system, followed by inhibition of the production of these cells by pro-inflammatory cytokines TNF-α, IL-1β, IL-6, B1-HMGB1 protein, macrophage-inflammatory protein-2-MIP-2 and decrease in mortality from sepsis were devoted to hundreds of articles by different authors [8,9,10,11]. The cholinergic anti-inflammatory pathway is realized due to the activation of acetylcholine m-acetylcholine receptors type 1 (m1AChR) of the brain, modulating the immunoregulatory function of the vagus nerve; excitation of efferent fibers n. Vagus; the action of acetylcholine on α7nAChRs cells of monocyte-macrophage system [3,6,7,12,13]. In cells of the monocyte-macrophage system, the anti-inflammatory effect is provided by the kinase JAK2, the transcription factor STAT3, the transcription factor NF-κB (nuclear factor kappa B, NF-kappa B) [3,6]
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