Abstract
After preloading with 3H-dopamine (DA) or 3H-serotonin (5HT)-striatal slices were re-indubated with non-radioactive amines (DA, 5HT, noradrenaline, histamine) or amino acids (GABA, glutamate, tyrosine, tryptophan). The effect or secondary uptake of most compounds on K +-stimulated release of 3H-DA and 3H-5HT was to either slightly or significantly increase the radioactivity retained in the tissue. This indicated a preferential release on stimulation of the non-radioactive compound taken up during the second incubation. On the contrary, the newly synthesised amines DA and 5HT, rather than their precursor amino acids, appeared to be more strongly bound than preloaded 3H-DA (but not 3H-5HT), being less easily released on K +-stimulation. The effect of reuptake on the further liberation of transmitter is discussed with reference to storage mechanisms.
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