Abstract
Abstract A series of 172 cases of oral cancer who had serial biopsies taken during a radical course of radiotherapy is reviewed. It was found that: (1) a prognosis based on early histological changes induced by radiation is in very good agreement with the clinical results of the initial treatment. (2) patients with differentiated tumours had a significantly higher five-year survival rate than those with anaplastic carcinomata; (3) lymph node involvement and persistence of precancerous lesions occurred less frequently in differentiated than in anaplastic cancers; (4) a higher percentage of patients with persistent precancer than of those without this lesion died ultimately of cancer but after a longer survival period than did patients with refractory tumours; (5) lymph node involvement did not affect the survival rate significantly in cases receiving equal radiation treatment at primary and secondary sites; (6) cancer persisted in the primary (with and without tumour in the nodes) in 85 per cent, but in th...
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