The Influence of the Sick House Syndrome on Nasal Mucosa and Nasal Symptoms

Abstract

Background and ObjectivesZZConcerns about the quality of indoor air have increased recently. However, there has not been any significant research conducted concerning the patterns of histologic and organic changes induced in humans by indoor air pollution. The aim of the study is to investigate the organic changes of nasal mucosa and nasal symptoms due to exposed concentrations of indoor air pollution. Subjects and MethodZZWe studied fourteen people from four families, all of whom had plans to move into new apartments. We measured the quantities of indoor air pollution before their move, one week after moving in, and then one month after the move. Other clinical tests such as an acoustic rhinometry, olfactory tests and nasal smears were performed. ResultsZZMean concentrations of Total Volatile Organic Chemicals (TVOCs) and aldehydes showed an increase after moving into the new apartments. Post-move acoustic rhinometry, Connecticut Chemosensory Clinical Research Center (CCCRC) test and endoscopic findings showed a decrease in nasal function and patency. Additionally, in nasal smears, eosinophils with bilobulated nuclei were observed, and eosinophil count showed a pattern of increase. ConclusionZZHigh concentrations of indoor air pollutants could induce organic changes of the nasal cavities and cause the recession of olfactory function. Due to indoor air pollutants, hypersensitivity of nasal mucosa was induced, and histological changes of nasal mucosa as well as hematological changes were observed. These indicate that indoor air pollution impinges on the nasal mucosa and cause nasal symptoms. � Korean J Otorhinolaryngol-Head Neck Surg 2011;54:265-70 Key WordsZZIndoor air pollution ㆍSick building syndrome ㆍAllergic rhinitis.