Abstract
We conclude that the antigonadotropic activity of the Sephadex G-25 fraction F3 seems to be fairly specific for the pineal body, but that it is unstable under the experimental conditions we have used. The Sephadex G-25 fraction F2 can be partly purified by chromatography on the cation exchanger Amberlite IRC-50, XE-64 and afterwards on the anion exchanger Dowex 1X2. The indoles (melatonin, 5-methoxy-tryptophol and serotonin-creatinine sulphate) show no activity in the bioassay that we always use. Experiments with synthetic arginine-vasotocin indicate that the action of this substance differs in vitro from that of the Sephadex G-25 fraction F3. It is not impossible that the inhibitory activity of the pineal is related to catecholamines.
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